Berberine is a plant compound that has shown impressive results for insulin resistance in PCOS — in some trials, comparable to metformin.
What the research shows:
• Improves insulin sensitivity (multiple RCTs) • Reduces fasting glucose and HbA1c • Lowers testosterone levels • Improves lipid profiles (reduces cholesterol and triglycerides) • May promote ovulation
Dose ranges in research: 500mg 2-3 times daily with meals. Starting at a lower dose and increasing gradually helps minimise GI side effects.
CRITICAL SAFETY INFORMATION:
• UNSAFE during pregnancy — berberine can stimulate uterine contractions. If you're trying to conceive, stop berberine before your fertile window. • Do NOT combine with metformin without medical supervision — both lower blood sugar, and the combination can cause dangerous hypoglycaemia. • Can interact with many medications — consult your doctor before starting. • Common side effects: GI issues (diarrhea, constipation, gas), similar to metformin.
Berberine has strong evidence for insulin resistance, but the safety considerations are more serious than other supplements. This is one to discuss thoroughly with your healthcare provider rather than self-prescribing.